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聯(lián)合用藥預防激素性股骨頭壞死對血漿一氧化氮含量的影響
【摘要】 目的 觀(guān)察聯(lián)合用藥預防激素性股骨頭壞死對血漿NO含量的影響，探討聯(lián)合用藥預防的作用機制。方法 30只兔隨機分成三組：對照組同期肌內注射生理鹽水；激素組是給予糖皮質(zhì)激素肌注；治療組在給予同劑量糖皮質(zhì)激素同時(shí)，每日使用血塞通、脂必妥和阿侖膦酸鈉；觀(guān)察股骨頭組織學(xué)變化，用免疫組化技術(shù)檢測血漿NO含量的變化。結果 激素組股骨頭軟骨下骨小梁稀疏、斷裂，脂肪細胞直徑增大，空骨陷窩較多，血漿NO含量顯著(zhù)低于對照組；治療組股骨頭軟骨下骨小梁結構較正常，血漿NO含量顯著(zhù)高于激素組。結論 聯(lián)合應用血塞通、脂必妥和阿侖膦酸鈉能預防和減緩激素性股骨頭的發(fā)生，血漿NO含量升高是聯(lián)合用藥預防的作用途徑之一。?
【關(guān)鍵詞】糖皮質(zhì)激素；股骨頭壞死；一氧化氮
Effect of drugs preventing steroid-induced osteonecrosis of the femoral head on the content of nitric oxide in plasma
CHEN Xiu-qin,LI Jing-tian,ZOU Jin-hui,et al.Department of Physiology,Medical College of Shaoguan University,Guangdong 512026,China
【Abstract】 Objective To observe the effect of drugs preventing steroid-induced osteonecrosis of the femoral head on the content of nitric oxide in plasma in order to investigate the role of the joint drug in the prevention mechanism.Methods Thirty rabbits were divided randomly into 3 groups:group A,guoup B and group C.Rabbits in group A were injected with normal saline; rabbits in group B were treated with glucocorticoid; rabbits in group C were treated with glucocorticoid as that in group B,and meanwhile,orally received the panax notoginseng saponins,zhibituo and alenduonate for 8 weeks.Histopathological structure and the content of nitric oxide in plasma were observed.Results The trabecula of femoral head of the B group changedthinner and more sparse,the bone marrow cavity with edema and large fatty cells were also observed and the content of nitric oxide in plasma of group B was significantly lower than those of group A.The trabecula of femoral head of the C group was normal and the content of nitric oxide in plasma of group C was significantly higher than those of group B.Conclusion The Zhibituo,Panax notoginseng saponins and Alenduonate may prevent steroid-induced necrosis of femoral head and the rising of the content of nitric oxide in plasma was one of the way of drugs preventing steroid-induced osteonecrosis of the femoral head.?
【Key words】Glucocorticoid; Necrosis of femoral; Nitric oxide
激素性股骨頭壞死的發(fā)病率占非創(chuàng )傷性股骨頭壞死首位，并有增高趨勢，已引起廣泛的重視。但目前關(guān)于激素性股骨頭缺血性壞死的研究多集中在治療已形成的壞死，對在使用激素過(guò)程中如何預防股骨頭壞死，研究較少[1]。本課題組在建立激素性股骨頭壞死動(dòng)物模型的過(guò)程中，采用血塞通、脂必妥和阿侖膦酸鈉聯(lián)合用藥進(jìn)行預防性治療，結果證實(shí)聯(lián)合用藥預防可提高股骨頭血流量，改善骨組織結構和血液流變學(xué)指標，預防或減緩激素性股骨頭壞死[2，3]。本實(shí)驗是進(jìn)一步觀(guān)察聯(lián)合用藥對血漿一氧化氮(nitric oxide，NO)含量的影響，探討聯(lián)合用藥預防激素性股骨頭壞死的作用機制。
1 材料和方法
1.1 實(shí)驗動(dòng)物 成年新西蘭大白兔30只，不分雌雄，體質(zhì)量(2.5
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